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R-22 has been the dominant refrigerant in residential and commercial air conditioning and some very large centrifugal chillers for air conditioning and industrial process cooling. It has also been used in refrigeration since the phase-out of CFCs, both as a pure refrigerant and in blends. R-22 is subject to reduced production and restriction in new equipment since 2010, and production ends in 2020. The use of R-22 is allowed until the R-22 supply has been depleted.